Metformin, rapamycin, NAD+ boosters, senolytics and why the basics still matter most.
Educational only: This page is not medical advice. Any medication or intervention should be discussed with a qualified clinician.
Some drugs and compounds are being studied for their influence on pathways related to aging biology. The science is active and promising in places, but not settled.
Metformin is a diabetes medication that influences insulin sensitivity and glucose metabolism. Some observational research suggests potential benefits beyond glucose control, but definitive longevity outcomes in humans remain under study.
Rapamycin targets the mTOR pathway, involved in growth and metabolism. Lifespan extension has been observed in animal models when mTOR signaling is altered, but human applications require careful consideration and more evidence.
NAD+ plays a role in energy metabolism and cellular repair. Supplements aim to support NAD+ availability, though long‑term human outcome data are limited.
Senolytics aim to clear senescent cells, cells that no longer divide but may contribute to inflammation and tissue dysfunction. Research is early and evolving.
Oroblend is a food‑based approach. It doesn’t attempt to mimic experimental drugs; it supports the foundational pathways with the best everyday evidence: nutrition quality, fiber, polyphenols, and habit consistency.
If you want the full framework how these ideas connect, where the research gets messy, and what a sustainable daily routine looks like in real life it's explored in the Oroblend book and newsletter.